- Last Updated on 14 December 2016
In some circumstances, other medications may be preferable to those discussed above. Most notably, if a specific metabolic disorder is discovered or suspected, there may be therapies of special utility for a particular disorder. As a example, in cases of pyridoxine responsive epilepsy, vitamin B6 (pyridoxine), pyridoxal-5-phosphate, or folinic acid can be highly effective.
More generally, there is limited data (uncontrolled clinical trials, anecdotal reports, etc.) in the scientific literature supporting the use of other common anti-seizure drugs, including: valproic acid (Depakene®, Depakote®), clobazam (Onfi®, Frisium®), clonazepam (Klonopin®), and felbamate (Felbatol®).
There are a variety of anti-seizure medications whose role in infantile spasms appears to be minimal, including lamotrigine (Lamictal®).
Among new medications, there is much interest in perampanel (Fycompa®), but no compelling scientific data to support is use in the treatment of infantile spasms.
This medication should be administered only under the direct supervision of a physician.