Other Medications

In some circumstances, other medications may be preferable to those discussed above. Most notably, if a specific metabolic disorder is discovered or suspected, there may be therapies of special utility for a particular disorder. As a example, in cases of pyridoxine responsive epilepsy, vitamin B6 (pyridoxine), pyridoxal-5-phosphate, or folinic acid can be highly effective.

More generally, there is limited data (uncontrolled clinical trials, anecdotal reports, etc.) in the scientific literature supporting the use of other common anti-seizure drugs, including: valproic acid (Depakene®, Depakote®), clobazam (Onfi®, Frisium®), clonazepam (Klonopin®), and felbamate (Felbatol®).

There are a variety of anti-seizure medications whose role in infantile spasms appears to be minimal, including lamotrigine (Lamictal®).

Among new medications, there is much interest in perampanel (Fycompa®), but no compelling scientific data to support is use in the treatment of infantile spasms.


This medication should be administered only under the direct supervision of a physician.

Although efforts are made to keep this website correct and up-to-date, we urge caution in interpreting the information you find here. This is in no way a substitute for the advice and care of a pediatric neurologist. Please view the terms of use.

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