Other Medications

In some circumstances, other medications may be preferable to those discussed above. Most notably, if a specific metabolic disorder is discovered or suspected, there may be therapies of special utility for a particular disorder. As a example, in cases of pyridoxine responsive epilepsy, vitamin B6 (pyridoxine), pyridoxal-5-phosphate, or folinic acid can be highly effective.

More generally, there is limited data (uncontrolled clinical trials, anecdotal reports, etc.) in the scientific literature supporting the use of other common anti-seizure drugs, including: valproic acid (Depakene®, Depakote®), clobazam (Onfi®, Frisium®), clonazepam (Klonopin®), and felbamate (Felbatol®).

There are a variety of anti-seizure medications whose role in infantile spasms appears to be minimal, including lamotrigine (Lamictal®).

Among new medications, there is much interest in perampanel (Fycompa®), but no compelling scientific data to support is use in the treatment of infantile spasms. Similarly, a new drug called everolimus has demonstrated effectiveness in the treatment of seizures associated with tuberous sclerosis complex (TSC), but not necessarily infantile spasms—with or without TSC.


This medication should be administered only under the direct supervision of a physician.

Although efforts are made to keep this website correct and up-to-date, we urge caution in interpreting the information you find here. This is in no way a substitute for the advice and care of a pediatric neurologist. Please view the terms of use.

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